Jurnal Review Aktivitas Antidiabetes dan Kandungan Senyawa Kimia dari Berbagai Bagian Tanaman Alpukat (Persea americana)
Keywords:
Persea americana, chemical compounds, antidiabetic activity
Abstract
Diabetes is a degenerative disease caused by unhealthy lifestyles in the case of type 2 diabetes. Hyperglycemia occurs due to endocrine disruption resulting in defective insulin secretion, insulin resistance or both. Avocado (Persea americana) has been known to have pharmacological activity, one of which is as an antidiabetic. Treatment using natural ingredients should be based on scientific evidence. This review journal was compiled from the online literature of local and international journals. Electronic search by keyword Persea americana, Plant Parts, Chemical Compounds and Antidiabetic Activity at several sites, such as NCBI, Elsevier and Pubmed. It is known that various parts of the Persea americana plant contain saponins, tannins, flavonoids, alkaloids, phenols and steroids. These compounds are responsible for various pharmacological activities that are caused.
References
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Ahmed Mashi, J. (2018). Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of P. americana Leaf in Alloxan-Induced
Diabetic Rats. International Journal of Biochemistry, Biophysics & Molecular Biology, 3(3), 45. https://doi.org/10.11648/j.ijbbmb.20180303.11
Aigbiremolen, A. A., Ativie, R. N., Aisuodionoe, M. E., & Odigie, O. M. (2018). Effect of Aqueous Extract of Persea americana Seed on Blood Glucose in Alloxan-induced Diabetic Wistar Rats. 9(3), 1–10. https://doi.org/10.9734/AJMAH/2017/37955
Alhassan, A. J., Sule, M. S., Atiku, M. K., Wudil, A. M., Abubakar, H., & Mohammed, S. A. (2012). Effects of aqueous avocado pear (Persea americana) seed extract on alloxan induced diabetes rats. Greener Journal of Medical Sciences, 2(1), 005–011. https://doi.org/10.15580/gjms.2012.1.gjms1202
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Brai, B. I. C., Odetola, A. A., & Agomo, P. U. (2007). Hypoglycemic and hypocholesterolemic potential of Persea americana leaf extracts. Journal of Medicinal Food, 10(2), 356–360. https://doi.org/10.1089/jmf.2006.291
Coelho, L. P., Reis, P. A., De Castro, F. L., Machado Gayer, C. R., Da Silva Lopes, C., Da Costa E Silva, M. C., … Pinto Coelho, M. G. (2005). Antinociceptive properties of ethanolic extract and fractions of Pterodon pubescens Benth. seeds. Journal of Ethnopharmacology, 98(1–2), 109–116. https://doi.org/10.1016/j.jep.2005.01.014
Edem, D. O., Ekanem, I. S., & Ebong, P. E. (2009). Effect of aqueous extracts of alligator pear seed (Persea americana Mill) on blood glucose and histopathology of pancreas in alloxan-induced diabetic rats. Pakistan Journal of Pharmaceutical Sciences, 22(3), 272–276.
Eliana, F., Fatimah, R. N., Energi, D., Makanan, K., Malang, K., Kahn, S. E., … Esposito, K. (2017). Carbohydrate Counting untuk Penderita Diabetes Mellitus dengan Terapi Insulin Menggunakan Algoritma Koloni Lebah Buatan. Therapeutic Advances in Endocrinology and Metabolism, 4(3), 1–12. https://doi.org/10.2337/dc12-0698
Ezejiofor, A. N., Okorie, A., & Orisakwe, O. E. (2013). Hypoglycaemic and tissue-protective effects of the aqueous extract of persea americana seeds on alloxan-induced albino rats. Malaysian Journal of Medical Sciences, 20(5), 31–39.
Ezuruike, U. F., & Prieto, J. M. (2014). The use of plants in the traditional management of diabetes in Nigeria : Pharmacological and toxicological considerations. Journal of Ethnopharmacology, 155(2), 857–924. https://doi.org/10.1016/j.jep.2014.05.055
Janice, D. A., John, A., & Jemmy, F. T. (2018). Morphological characteristics of avocado (Persea americana Mill.) in Ghana. African Journal of Plant Science, 12(4), 88–97. https://doi.org/10.5897/ajps2017.1625
Lahlou, M. (2013). The Success of Natural Products in Drug Discovery. Pharmacology & Pharmacy, 04(03), 17–31. https://doi.org/10.4236/pp.2013.43a003
Lima, C. R., Vasconcelos, C. F. B., Costa-Silva, J. H., Maranhão, C. A., Costa, J., Batista, T. M., … Wanderley, A. G. (2012). Anti-diabetic activity of extract from Persea americana Mill. leaf via the activation of protein kinase B (PKB/Akt) in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 141(1), 517–525. https://doi.org/10.1016/j.jep.2012.03.026
Mamadou, K., N’Goran, M. K., Eugene, K., Amani, B. K., Koffi, C., N’Guessan, A. R. Y., … Henri, M. D.-K. (2016). Acute toxicity and hypoglycaemic activity of the leaf extracts of Persea americana Mill. (Lauraceae) in Wistar rats. African Journal of Pharmacy and Pharmacology, 10(33), 690–698. https://doi.org/10.5897/ajpp2016.4617
Mashi, J. A., Atiku, M. K., Shehu, D., Idris, R. I., Sa`id, A. M., Dangambo, M. A., … Babandi, A. (2019). Comparative Study of Different Solvents Extract of Persea americana Leaf on Alloxan Induced Hyperglycemic Rats. Asian Journal of Biological Sciences, 12(1), 67–72. https://doi.org/10.3923/ajbs.2019.67.72
Njateng, G. S. S., Zaib, S., Chimi, L., Feudjio, C., Mouokeu, R. S., Gatsing, D., … Iqbal, J. (2018). Antidiabetic potential of methanol extracts from leaves of Piper umbellatum L. and Persea americana Mill. Asian Pacific Journal of Tropical Biomedicine, 8(3), 160–165. https://doi.org/10.4103/2221-1691.227997
Noorul, H., Nesar, A., Zafar, K., Khalid, M., Zeeshan, A., & Vartika, S. (2016). International Journal of Research in Health benefits and pharmacology of Persea americana mill . ( Avocado ). 5(2), 132–141.
Shirly Kumala, H. U. and W. K. S. (2013). The Effect Of Avocado (Persea Americana Mill.) Leaves Extract Towards The Mouse’s Blood Glucose Decrease With The Glucose Tolerance Method. Pharmacy Faculty, Pancasila University, Jakarta. Intl J Pharm Sci Res, 4(2), 661–665.
Tene Tcheghebe, O., Nyamen, L. D., Ngouafong Tatong, F., & Seukep, A. J. (2016). Ethnobotanical uses, phytochemical and pharmacological profiles, and toxicity of persea Americana mill.: An overview. Pharmacologyonline, 3(January), 213–221.
Thenmozhi, A., Shanmugasundaram, C., & Mahadeva Rao, U. S. (2012). Biochemical evaluation of anti-diabetic phytomolecule through bioactivity guided solvent fractionation and subfractionation from hydro-methanolic (2:3) extract of alligator pear fruit in streptozotocin induced diabetic rats. Journal of Applied Pharmaceutical Science, 2(1), 61–69.
Arukwe, U., Amadi, B.A., Duru, M. K.C., Agomuo,E.N., Adindu, E. A., Odika, P.C., Lele, K.C., Egejuru, L., and Anudike, J. (2012). Chemical Composition of Persea Americana Leaf , Fruit and Seed. Ijrras, 11(May), 346–349.
Upadhyay, R. K. (2016). Antidiabetic potential of plant natural products: A review. International Journal of Green Pharmacy, 10(3), S96–S113
Ahmed Mashi, J. (2018). Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of P. americana Leaf in Alloxan-Induced
Diabetic Rats. International Journal of Biochemistry, Biophysics & Molecular Biology, 3(3), 45. https://doi.org/10.11648/j.ijbbmb.20180303.11
Aigbiremolen, A. A., Ativie, R. N., Aisuodionoe, M. E., & Odigie, O. M. (2018). Effect of Aqueous Extract of Persea americana Seed on Blood Glucose in Alloxan-induced Diabetic Wistar Rats. 9(3), 1–10. https://doi.org/10.9734/AJMAH/2017/37955
Alhassan, A. J., Sule, M. S., Atiku, M. K., Wudil, A. M., Abubakar, H., & Mohammed, S. A. (2012). Effects of aqueous avocado pear (Persea americana) seed extract on alloxan induced diabetes rats. Greener Journal of Medical Sciences, 2(1), 005–011. https://doi.org/10.15580/gjms.2012.1.gjms1202
Antia, B. S., Okokon, J. E., & Okon, P. A. (2005). Hypoglycemic activity of aqueous leaf extract of Persea americana mill [1]. Indian Journal of Pharmacology, 37(5), 325–326. https://doi.org/10.4103/0253-7613.16858
Brai, B. I. C., Odetola, A. A., & Agomo, P. U. (2007). Hypoglycemic and hypocholesterolemic potential of Persea americana leaf extracts. Journal of Medicinal Food, 10(2), 356–360. https://doi.org/10.1089/jmf.2006.291
Coelho, L. P., Reis, P. A., De Castro, F. L., Machado Gayer, C. R., Da Silva Lopes, C., Da Costa E Silva, M. C., … Pinto Coelho, M. G. (2005). Antinociceptive properties of ethanolic extract and fractions of Pterodon pubescens Benth. seeds. Journal of Ethnopharmacology, 98(1–2), 109–116. https://doi.org/10.1016/j.jep.2005.01.014
Edem, D. O., Ekanem, I. S., & Ebong, P. E. (2009). Effect of aqueous extracts of alligator pear seed (Persea americana Mill) on blood glucose and histopathology of pancreas in alloxan-induced diabetic rats. Pakistan Journal of Pharmaceutical Sciences, 22(3), 272–276.
Eliana, F., Fatimah, R. N., Energi, D., Makanan, K., Malang, K., Kahn, S. E., … Esposito, K. (2017). Carbohydrate Counting untuk Penderita Diabetes Mellitus dengan Terapi Insulin Menggunakan Algoritma Koloni Lebah Buatan. Therapeutic Advances in Endocrinology and Metabolism, 4(3), 1–12. https://doi.org/10.2337/dc12-0698
Ezejiofor, A. N., Okorie, A., & Orisakwe, O. E. (2013). Hypoglycaemic and tissue-protective effects of the aqueous extract of persea americana seeds on alloxan-induced albino rats. Malaysian Journal of Medical Sciences, 20(5), 31–39.
Ezuruike, U. F., & Prieto, J. M. (2014). The use of plants in the traditional management of diabetes in Nigeria : Pharmacological and toxicological considerations. Journal of Ethnopharmacology, 155(2), 857–924. https://doi.org/10.1016/j.jep.2014.05.055
Janice, D. A., John, A., & Jemmy, F. T. (2018). Morphological characteristics of avocado (Persea americana Mill.) in Ghana. African Journal of Plant Science, 12(4), 88–97. https://doi.org/10.5897/ajps2017.1625
Lahlou, M. (2013). The Success of Natural Products in Drug Discovery. Pharmacology & Pharmacy, 04(03), 17–31. https://doi.org/10.4236/pp.2013.43a003
Lima, C. R., Vasconcelos, C. F. B., Costa-Silva, J. H., Maranhão, C. A., Costa, J., Batista, T. M., … Wanderley, A. G. (2012). Anti-diabetic activity of extract from Persea americana Mill. leaf via the activation of protein kinase B (PKB/Akt) in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 141(1), 517–525. https://doi.org/10.1016/j.jep.2012.03.026
Mamadou, K., N’Goran, M. K., Eugene, K., Amani, B. K., Koffi, C., N’Guessan, A. R. Y., … Henri, M. D.-K. (2016). Acute toxicity and hypoglycaemic activity of the leaf extracts of Persea americana Mill. (Lauraceae) in Wistar rats. African Journal of Pharmacy and Pharmacology, 10(33), 690–698. https://doi.org/10.5897/ajpp2016.4617
Mashi, J. A., Atiku, M. K., Shehu, D., Idris, R. I., Sa`id, A. M., Dangambo, M. A., … Babandi, A. (2019). Comparative Study of Different Solvents Extract of Persea americana Leaf on Alloxan Induced Hyperglycemic Rats. Asian Journal of Biological Sciences, 12(1), 67–72. https://doi.org/10.3923/ajbs.2019.67.72
Njateng, G. S. S., Zaib, S., Chimi, L., Feudjio, C., Mouokeu, R. S., Gatsing, D., … Iqbal, J. (2018). Antidiabetic potential of methanol extracts from leaves of Piper umbellatum L. and Persea americana Mill. Asian Pacific Journal of Tropical Biomedicine, 8(3), 160–165. https://doi.org/10.4103/2221-1691.227997
Noorul, H., Nesar, A., Zafar, K., Khalid, M., Zeeshan, A., & Vartika, S. (2016). International Journal of Research in Health benefits and pharmacology of Persea americana mill . ( Avocado ). 5(2), 132–141.
Shirly Kumala, H. U. and W. K. S. (2013). The Effect Of Avocado (Persea Americana Mill.) Leaves Extract Towards The Mouse’s Blood Glucose Decrease With The Glucose Tolerance Method. Pharmacy Faculty, Pancasila University, Jakarta. Intl J Pharm Sci Res, 4(2), 661–665.
Tene Tcheghebe, O., Nyamen, L. D., Ngouafong Tatong, F., & Seukep, A. J. (2016). Ethnobotanical uses, phytochemical and pharmacological profiles, and toxicity of persea Americana mill.: An overview. Pharmacologyonline, 3(January), 213–221.
Thenmozhi, A., Shanmugasundaram, C., & Mahadeva Rao, U. S. (2012). Biochemical evaluation of anti-diabetic phytomolecule through bioactivity guided solvent fractionation and subfractionation from hydro-methanolic (2:3) extract of alligator pear fruit in streptozotocin induced diabetic rats. Journal of Applied Pharmaceutical Science, 2(1), 61–69.
Arukwe, U., Amadi, B.A., Duru, M. K.C., Agomuo,E.N., Adindu, E. A., Odika, P.C., Lele, K.C., Egejuru, L., and Anudike, J. (2012). Chemical Composition of Persea Americana Leaf , Fruit and Seed. Ijrras, 11(May), 346–349.
Upadhyay, R. K. (2016). Antidiabetic potential of plant natural products: A review. International Journal of Green Pharmacy, 10(3), S96–S113
Published
2019-06-25
How to Cite
Sujana, D., Nurul, N., & Ramdani, hasbi. (2019). Jurnal Review Aktivitas Antidiabetes dan Kandungan Senyawa Kimia dari Berbagai Bagian Tanaman Alpukat (Persea americana). Jurnal Medika Cendikia, 6(01), 76-81. https://doi.org/10.33482/medika.v6i01.104
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Articles
Copyright (c) 2019 hasbi Taobah Ramdani
This work is licensed under a Creative Commons Attribution 4.0 International License.
